San Francisco! The city by the bay, the city full of gays, and residual purple haze, and so forth.
I visited SF for just a day ten years ago, expecting to want to move there, hit mostly tourist spots and only found it okay at the time. This visit I had slightly more time and a native tour guide, and came away loving the city and wanting more. (I wish many of my trips weren't so brief, as it's not the ideal way to see the world, but it's better than not visiting at all.)
My native tour guide was Maggie of SXSW blog-post fame, who is officially the best San Fran tour guide possible. One highlight was brunch at Absinthe in Hayes Valley (below), where Jamie from Top Chef is executive chef, which rocked. Your girl over here tried a first few teeny orbs of caviar, and found them intriguing.